Creamy Chicken Alfredo Lasagna: The Ultimate Comfort Food Recipe

Indulge in the rich, comforting embrace of homemade **Creamy Chicken Alfredo Lasagna**. This irresistible dish layers tender, juicy chicken with creamy ricotta cheese, fresh spinach, and perfectly cooked lasagna noodles, all bathed in a luscious, cheesy homemade Alfredo sauce. It’s a hearty and satisfying meal that promises to become a cherished favorite for family dinners and special occasions alike. Forget boring weeknights; this casserole brings gourmet flavor right to your table!

Drawing inspiration from beloved Italian-American classics, this recipe elevates the traditional lasagna experience with a decadent white sauce twist. If you adore the flavors of my one-pan chicken spinach Alfredo, you’ll fall head over heels for this baked casserole version. For more effortless chicken pasta dinners, don’t miss these delightful chicken stuffed shells or my time-tested easy weeknight lasagna recipe.

When it comes to homemade lasagna, this rendition featuring a rich white sauce has quickly claimed its spot as a new family favorite. Our Chicken Alfredo Lasagna masterfully blends a creamy, from-scratch Alfredo sauce with succulent chicken, vibrant spinach, and delightful layers of fluffy ricotta cheese and tender lasagna noodles. The heart of the filling comes together effortlessly in a single skillet before being meticulously layered and baked to golden perfection in a casserole dish. It’s a deceptively quick and easy dinner that bursts with incredible flavor, offering generous helpings of gooey, melty cheese in every forkful.

Why This Chicken Alfredo Lasagna is a Must-Try

There are countless reasons to add this Chicken Alfredo Lasagna to your regular meal rotation. It’s not just a meal; it’s an experience that brings warmth and joy to your dining table.

• The Epitome of Comfort Food: Few dishes rival the comforting warmth and satisfaction of a homemade lasagna. This Chicken Alfredo Lasagna takes that comfort to the next level with its decadent, cheesy layers, generously packed with tender chicken and nutritious spinach. It truly is a satisfying, all-in-one meal that feels like a hug from the inside out, perfect for chilly evenings or simply when you need a little extra cheer.
• Superior Homemade Alfredo Sauce: While store-bought Alfredo sauce offers convenience, nothing compares to the rich, nuanced flavor of a homemade version. Crafting this classic, creamy sauce from scratch requires minimal effort and time, yet yields truly remarkable results. My recipe utilizes simple, everyday ingredients and comes together in mere minutes on your stovetop. It’s incredibly versatile, serving as the perfect base for everything from classic fettuccine Alfredo to this spectacular lasagna. The difference in taste and texture is 100% worth the extra step!
• A Guaranteed Family Pleaser: The mild, inviting flavors of this cheesy chicken lasagna make it an absolute crowd-pleaser for all ages. It’s a fantastic option for picky eaters and sophisticated palates alike. Kids adore the creamy sauce and abundance of cheese, while adults can’t resist its rich, luxurious texture and hearty ingredients. It’s the ideal dish to unite everyone around the dinner table.
• Easy to Prepare: Despite its impressive appearance and gourmet taste, this lasagna is surprisingly straightforward to prepare. With clear, step-by-step instructions, even novice cooks can create a masterpiece. Many components can be prepped ahead of time, making assembly a breeze on a busy weeknight.
• Customizable and Versatile: This recipe serves as an excellent foundation for customization. Feel free to incorporate additional vegetables, experiment with different cheeses, or adjust the seasonings to suit your family’s preferences. It’s a dish that encourages creativity in the kitchen!

Essential Ingredients for Your Alfredo Lasagna

Crafting this delicious chicken Alfredo lasagna is simple, requiring only a few readily available ingredients. Here are some detailed notes to help you choose the best components. For a complete, printable list with precise measurements, please refer to the recipe card below.

• Homemade Alfredo Sauce: The heart of this dish! My recipe for quick homemade Alfredo sauce is included for its unparalleled richness and flavor. However, if time is of the essence, two jars of your favorite high-quality store-bought Alfredo sauce can be used as a convenient substitute. Just be sure to warm it gently before incorporating it into the dish.
• Spinach: Fresh baby spinach is my go-to for its delicate texture and vibrant color. For a heartier alternative, chopped chard works wonderfully. If using frozen spinach, ensure it’s thoroughly thawed and excess water is squeezed out to prevent a watery lasagna. This step is crucial for maintaining the lasagna’s creamy consistency.
• Cooked Chicken: Any cooked chicken will do, making this recipe perfect for using up leftovers. I often prepare this lasagna when I have extra roast chicken or Instant Pot whole chicken in the refrigerator. A pre-cooked rotisserie chicken, diced or shredded, is another fantastic time-saving option, adding a lovely depth of flavor.
• Ricotta Cheese: This mild, creamy Italian soft cheese forms a key layer, adding moisture and a subtle sweetness. If ricotta isn’t available, full-fat cottage cheese (drained well) makes an excellent and widely accessible substitute. The texture will be slightly different, but the flavor will still be delicious.
• Egg: A single large egg is mixed with the ricotta cheese to bind it together, ensuring the cheesy layer sets beautifully during baking and doesn’t become too crumbly.
• Seasoning: I always keep a jar of my homemade Italian seasoning in the pantry; it’s incredibly easy to make and far superior to store-bought blends. However, feel free to use your preferred high-quality store-bought herb blend to season the ricotta layer. Freshly ground black pepper and a pinch of nutmeg can also enhance the Alfredo sauce.
• Lasagna Noodles: Opt for your favorite brand of classic lasagna noodles. While no-boil noodles can save time, boiling traditional noodles ensures a more tender and consistent texture throughout the baked dish. Remember to boil them al dente, as they will continue to cook in the oven.
• Mozzarella Cheese: For the best melting and stretch, I highly recommend shredding fresh mozzarella from a block rather than using pre-shredded packaged cheese. Pre-shredded cheese often contains anti-caking agents that can hinder smooth melting, resulting in a less desirable texture. Freshly shredded mozzarella guarantees that wonderfully gooey, melty cheese pull we all crave!

Step-by-Step Guide to Making Chicken Alfredo Lasagna

Like all the most celebrated lasagna recipes, building layers of flavor is paramount for this dish. Follow these detailed steps to create a truly memorable meal. For comprehensive, printable instructions, please scroll down to the full recipe card.

• Prepare Your Noodles: Begin by bringing a large pot of salted water to a rolling boil. Add your lasagna noodles and cook them for approximately 8 minutes, or according to the package directions, aiming for an al dente texture. Drain the noodles thoroughly and, to prevent them from sticking together, toss them gently with a small amount of olive oil. Set them aside while you prepare the other components. This ensures your noodles are pliable and ready for layering.
• Craft the Luscious Alfredo Sauce: In a large, deep skillet, melt two tablespoons of butter over medium-high heat. Add the finely diced onion and sauté for 3-4 minutes until it begins to soften and become translucent, releasing its sweet aroma. Stir in the minced garlic and cook for another minute, being careful not to burn it – you’ll know it’s ready when you can smell its fragrant essence. Next, pour in the heavy cream and bring the mixture to a gentle simmer, stirring occasionally. Avoid a rolling boil. Once simmering, gradually whisk in the grated Parmesan cheese until it’s completely melted and the sauce is smooth and slightly thickened. Season generously with salt and freshly ground black pepper to taste.

• Incorporate Chicken and Spinach: Once your Alfredo sauce is perfected, stir in the cooked, shredded or diced chicken and the fresh baby spinach. Continue to cook for just a couple of minutes, allowing the spinach to wilt and become tender. Remove the skillet from the heat immediately after the spinach has wilted to prevent overcooking. Adjust seasoning one last time if necessary.
• Prepare the Ricotta Mixture: In a separate medium-sized bowl, combine the ricotta cheese, one large egg, and the Italian seasoning. Mix thoroughly with a spoon or spatula until all ingredients are well combined and the mixture is smooth. The egg acts as a binder, helping the ricotta layer to set beautifully during baking.

• Masterful Assembly: Preheat your oven to 375°F (190°C). Grab a 9×13-inch (or similar size) casserole dish. Start by spooning a thin layer (about ¼ cup) of the chicken Alfredo sauce onto the bottom of the dish to prevent sticking and add flavor. Next, arrange three cooked lasagna noodles in a single layer over the sauce. Spread one-third of the ricotta mixture evenly over the noodles. Follow with another generous layer of chicken Alfredo sauce (about one-third of the remaining sauce), then sprinkle with a good amount of shredded mozzarella cheese. Repeat this layering process two more times, ensuring you use all the remaining ingredients. Finish the top layer with a final spread of Alfredo sauce and a generous covering of mozzarella cheese.

• Bake to Perfection: Cover the casserole dish tightly with aluminum foil. Place your chicken Alfredo lasagna into the preheated 375°F (190°C) oven and bake for 40-45 minutes. The edges should be visibly hot and bubbly. For that irresistible golden-brown, slightly crispy top, carefully remove the foil during the last 5 minutes of baking. You can also briefly broil it for 2-3 minutes, keeping a close eye to prevent burning.
• Rest Before Serving: Once baked, remove the lasagna from the oven. This step is crucial: let the lasagna rest for at least 10-15 minutes before slicing and serving. This resting period allows the layers to settle and the sauce to thicken slightly, resulting in cleaner slices and less “soupy” servings. It’s a small wait for a big payoff in presentation and texture!

Expert Tips and Recipe Notes

Unlock the full potential of your Chicken Alfredo Lasagna with these helpful hints and variations:

• The Importance of Resting: As mentioned in the steps, allowing the lasagna to cool and set for 10-15 minutes after it comes out of the oven is non-negotiable. This brief rest period helps the layers to firm up and the sauce to absorb, preventing your slices from being overly runny. Patience here yields perfectly structured, delicious servings.
• Time-Saving Shortcut: For those exceptionally busy evenings, instead of preparing Alfredo sauce from scratch, you can heat two jars (about 25-30 ounces total) of good quality store-bought Alfredo sauce on the stovetop. Once warmed through, stir in your cooked chicken and spinach, and proceed with assembly as usual. While homemade is always best, this shortcut ensures you can still enjoy this delightful dish.
• Boost Your Veggies: Easily add more nutrition and flavor by incorporating additional cooked vegetables into the chicken Alfredo layer. Sautéed bell peppers, steamed broccoli florets (similar to my chicken broccoli Alfredo), mushrooms, or even finely chopped zucchini would be excellent additions. Ensure any added vegetables are cooked until tender-crisp before mixing into the sauce to avoid adding excess moisture.
• Spice Things Up: Don’t be afraid to experiment with different spice blends to customize the flavor profile. Sometimes, I’ll swap the Italian seasoning in the ricotta layer for a fiery kick of homemade Cajun spice. This creates a fantastic variation reminiscent of Cajun chicken Alfredo, adding a unique depth and warmth. A pinch of red pepper flakes in the Alfredo sauce can also provide a subtle heat.
• Make Ahead Tips: You can assemble the entire lasagna up to 24 hours in advance. Cover it tightly with foil and refrigerate. When ready to bake, add an extra 10-15 minutes to the covered baking time, ensuring it’s heated through before uncovering for the final browning.
• Cheese Varieties: While mozzarella is classic, consider adding a layer of provolone or a blend of Italian cheeses for extra complexity. A sprinkle of freshly grated Asiago or Pecorino Romano over the top before broiling can also add a sharp, salty finish.

Perfect Serving Suggestions

This chicken Alfredo lasagna is a meal in itself, but pairing it with complementary sides can elevate the dining experience to a whole new level. It’s ideal as a comforting weeknight dinner or a centerpiece for entertaining.

• Crisp Green Salad: A light, refreshing salad provides a wonderful contrast to the richness of the lasagna. A classic Caesar salad with its tangy dressing and crunchy croutons is always a winner. Alternatively, a simple mixed green salad with a vinaigrette dressing would be perfect.
• Garlic Bread or Breadsticks: You simply cannot have lasagna without something to sop up every last bit of that amazing sauce! Soft, pillowy breadsticks or crispy air fryer garlic bread are absolute must-haves. The garlicky goodness complements the creamy Alfredo beautifully.
• Steamed or Roasted Vegetables: To round out the meal, offer a side of vibrant vegetables. Steamed broccoli, tender roasted green beans with sesame and garlic, or delicate sautéed asparagus are excellent choices that add color and freshness without overpowering the main dish.
• A Touch of Sweetness: For dessert, you absolutely can’t go wrong with a batch of rich, chewy fudgy brownies or a light panna cotta to cleanse the palate.
• Beverage Pairings: A crisp, dry white wine like Chardonnay or Sauvignon Blanc would beautifully cut through the richness of the Alfredo. For non-alcoholic options, sparkling cider or even a simple iced tea would be refreshing.

Storing and Reheating Leftovers

While this chicken Alfredo lasagna is undoubtedly at its peak creaminess and flavor on the day it’s made, any leftovers can still be enjoyed with proper storage and reheating.

• Refrigeration: The sauce, due to its dairy content, tends to become a little grainier after refrigeration. However, this doesn’t diminish its deliciousness. If you have leftovers, allow the lasagna to cool completely, then cover it tightly with an airtight lid or plastic wrap. Store in the refrigerator for up to 2-3 days.
• Reheating: To reheat individual slices, the oven is generally preferred for best results. Place slices in an oven-safe dish, cover loosely with foil, and warm at 300°F (150°C) for about 15-20 minutes, or until heated through. For a quicker option, slices can be microwaved. Place a slice on a microwave-safe plate, cover with a damp paper towel (this helps retain moisture), and heat in 1-2 minute intervals until hot. Be aware that microwave reheating might alter the texture slightly more than oven reheating.
• Freezing: I generally do not recommend freezing this particular chicken Alfredo lasagna. For the same reason it’s best served fresh (dairy-heavy sauces can change texture upon thawing), freezing can significantly impact the quality. The creamy Alfredo sauce, rich with heavy cream and Parmesan, tends to separate or become grainy once frozen and then thawed. While it won’t be unsafe to eat, the luxurious texture you enjoyed initially won’t be the same. If you absolutely must freeze it, understand that the texture may be compromised.

More Delicious Chicken Recipes

If you’re a fan of versatile chicken dishes, explore these other fantastic recipes from my collection:

• Bruschetta Chicken Pasta
• Chicken Spaghetti
• Chicken Cordon Bleu Pasta
• Buffalo Chicken Pasta
• Chicken Bacon Ranch Pasta

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Chicken Alfredo Lasagna

By Erin Sellin

Creamy, cheesy chicken alfredo lasagna combines homemade alfredo sauce with juicy chicken and spinach, layered with ricotta and tender lasagna noodles, creating the ultimate comforting casserole.

Prep: 15 minutes mins

Cook: 1 hour hr

Total: 1 hour hr 15 minutes mins

Servings: 6 servings

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Ingredients 

Alfredo Sauce

• ▢ 2 Tablespoons butter
• ▢ ½ cup finely chopped onion
• ▢ 2 cloves garlic, minced
• ▢ 3 cups heavy cream
• ▢ 2 cups Parmesan cheese
• ▢ Salt & pepper to taste
• ▢ 2 cups baby spinach
• ▢ 2 cups cooked chicken

Ricotta Layer & Assembly

• ▢ 1 cup ricotta cheese
• ▢ 1 whole large egg
• ▢ ½ teaspoon Italian seasoning
• ▢ 9 lasagna noodles
• ▢ 2 cups shredded Mozzarella cheese

Instructions 

• Preheat your oven to 375º F (190°C).
• Bring a large pot of lightly salted water to a boil. Add the lasagna noodles and cook for approximately 8 minutes, or according to package directions, until al dente. Drain the noodles and toss with a touch of olive oil to prevent sticking, then set aside.
  9 lasagna noodles
• In a large, deep skillet, melt the butter over medium-high heat. Add the finely chopped onion and sauté for 3-4 minutes until it begins to soften and become translucent. Stir in the minced garlic and cook for another minute until fragrant.
  2 Tablespoons butter, ½ cup finely chopped onion, 2 cloves garlic
• Pour in the heavy cream and bring the mixture to a gentle simmer (do not boil). Gradually whisk in the Parmesan cheese until it melts and the sauce is smooth and creamy. Season the sauce with salt and pepper to taste. Stir in the cooked chicken and baby spinach, cooking for just a couple of minutes until the spinach wilts. Remove the skillet from the heat.
  3 cups heavy cream, 2 cups Parmesan cheese, Salt & pepper to taste, 2 cups baby spinach, 2 cups cooked chicken
• In a separate medium bowl, combine the ricotta cheese, one whole large egg, and ½ teaspoon of Italian seasoning. Mix until all ingredients are well combined and smooth.
  1 cup ricotta cheese, 1 whole large egg, ½ teaspoon Italian seasoning
• To assemble the lasagna, spoon about ¼ cup of the chicken Alfredo sauce into the bottom of a 9×13-inch (or 10×7-inch as used in notes) baking dish and spread it evenly. Lay 3 cooked lasagna noodles in a single layer over the sauce. Spread 1/3 of the ricotta mixture evenly over the noodles. Top with about 1/3 of the remaining chicken Alfredo sauce and sprinkle generously with shredded Mozzarella cheese. Repeat this layering process two more times, creating three full layers.
  2 cups shredded Mozzarella cheese
• Cover the baking dish tightly with aluminum foil. Bake for 40-45 minutes in the preheated oven, or until the lasagna is hot and bubbly around the edges. For a golden-brown, crispy cheese topping, remove the foil and broil for the last 5 minutes (watch carefully to prevent burning).
• Once baked, remove the lasagna from the oven and let it stand for 10-15 minutes before slicing and serving. This allows the layers to set, making for cleaner and more beautiful servings.

Notes

• I used a 10×7-inch baking dish for a thicker lasagna, but a standard 9×13-inch dish works perfectly for a slightly flatter result.
• Time-saving tip: If you’re pressed for time, simply heat 2 jars of your preferred store-bought alfredo sauce. Once warm, stir in the cooked chicken and spinach, then proceed with the recipe.

Nutrition

Calories: 1006kcal | Carbohydrates: 40g | Protein: 47g | Fat: 74g | Saturated Fat: 45g | Polyunsaturated Fat: 4g | Monounsaturated Fat: 20g | Trans Fat: 0.2g | Cholesterol: 280mg | Sodium: 922mg | Potassium: 509mg | Fiber: 2g | Sugar: 6g | Vitamin A: 3562IU | Vitamin C: 5mg | Calcium: 784mg | Iron: 2mg

Nutrition information is automatically calculated, so should only be used as an approximation.

Additional Info

Author: Erin Sellin

Prep Time: 15 minutes minutes

Cook Time: 1 hour hour

Total Time: 1 hour hour 15 minutes minutes

Course: Dinner Recipes

Cuisine: American

Servings: 6 servings

Calories: 1006

Keyword: chicken alfredo lasagna, creamy lasagna, homemade alfredo, weeknight dinner

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